Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3387 | 0.3387 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.3387 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.3387 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3387 | 0.3387 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.3387 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.3387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.3387 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3387 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.3387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay | ChEMBL. | 18571929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.