Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0736 | 0.422 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1694 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0736 | 0.422 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0083 | 0.0196 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1159 | 0.1159 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0083 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0083 | 0.0196 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1694 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0736 | 0.422 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0083 | 0.0196 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0736 | 0.422 | 1 |
Mycobacterium leprae | Isocitrate lyase | 0.0794 | 0.4573 | 0.4573 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0736 | 0.422 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1694 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1694 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1694 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.