Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0064 | 0.014 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0057 | 0.0729 | 0.1584 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0462 | 0.066 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.3411 | 0.8937 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0462 | 0.0877 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0462 | 0.0877 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.1044 |
Onchocerca volvulus | 0.0048 | 0.0462 | 0.6683 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0462 | 0.066 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0747 | 0.0358 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.2199 | 0.3206 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0462 | 0.0181 |
Echinococcus granulosus | expressed protein | 0.0068 | 0.1106 | 0.0407 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0462 | 0.0877 |
Trichomonas vaginalis | rotamase, putative | 0.0068 | 0.1106 | 1 |
Onchocerca volvulus | 0.005 | 0.0514 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1151 | 0.1801 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0057 | 0.0729 | 0.1584 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0462 | 0.0181 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0139 | 0.3411 | 0.2893 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0068 | 0.1106 | 0.1727 |
Brugia malayi | hypothetical protein | 0.0222 | 0.6099 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6099 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0067 | 0.1054 | 0.0638 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.3774 | 0.3284 |
Echinococcus multilocularis | tumor protein p63 | 0.0342 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.011 | 0.2461 | 0.3662 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1697 | 0.2706 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.3774 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0334 | 0.9739 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2461 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.3774 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0067 | 0.1054 | 0.3928 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0462 | 0.0877 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4023 | 0.3871 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.2199 | 0.3537 |
Schistosoma mansoni | rotamase | 0.0068 | 0.1106 | 0.2189 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1151 | 0.2321 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.4023 | 0.3871 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.1044 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0057 | 0.0729 | 0.2161 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0067 | 0.1054 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2461 | 0.6154 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1151 | 0.1381 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0514 | 0.0455 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0086 | 0.1697 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0067 | 0.1054 | 0.0687 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0462 | 0.0181 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0139 | 0.3411 | 0.2893 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.2199 | 0.3206 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0334 | 0.9739 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0067 | 0.1054 | 0.0687 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.2461 | 0.1867 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.3598 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2461 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0462 | 0.0877 |
Echinococcus multilocularis | expressed protein | 0.0068 | 0.1106 | 0.0407 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.1697 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.4604 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4023 | 0.3838 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0462 | 0.0877 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.2461 | 0.1867 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1106 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0462 | 0.1004 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.1697 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0222 | 0.6099 | 0.5792 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.9739 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.2461 | 0.6154 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.9739 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.1697 | 0.3598 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0462 | 0.1004 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0462 | 0.0877 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0086 | 0.1697 | 0.392 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.4604 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2461 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0067 | 0.1054 | 0.2961 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.2199 | 0.3537 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0222 | 0.6099 | 0.5792 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0462 | 0.066 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0514 | 0.0745 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0068 | 0.1106 | 0.1303 |
Brugia malayi | Probable ClpP-like protease | 0.0086 | 0.1697 | 0.2332 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0462 | 0.0877 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0086 | 0.1697 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.12 | Trypanocidal activity against Trypanosoma cruzi Y in Swiss albino mouse blood after 24 hrs | ChEMBL. | 19036592 |
IC50 (functional) | = 0.76 mM | Trypanocidal activity against Trypanosoma cruzi Y in Swiss albino mouse blood after 24 hrs | ChEMBL. | 19036592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.