Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.533 | 0.4775 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.533 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1062 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0032 | 0.533 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3135 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3135 | 0.2319 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.1062 | 0.1062 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.1062 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1062 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3135 | 0.3135 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.08 pmol | Activation of human recombinant sGC subunit alpha-1/beta-1 using GTP as substrate assessed as cGMP production measured per ng of protein at 100 uM treated prior to DEA/NO addition measured after 2 mins by radioimmunoassay in presence of Mg2+ (Rvb = 2.21 +/- 0.15 pmol) | ChEMBL. | 24480469 |
Occ (binding) | = 94 % | Binding affinity to sGC subunit alpha-1/beta-1 catalytic domain (unknown origin) assessed as occupancy relative to control | ChEMBL. | 24480469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.