Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.584 | 0.6194 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.8855 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0057 | 0.1834 | 0.1834 |
Mycobacterium ulcerans | putative regulatory protein | 0.0042 | 0.0933 | 0.3799 |
Schistosoma mansoni | amidase | 0.0123 | 0.584 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0067 | 0.2456 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.8855 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.8855 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0067 | 0.2456 | 0.2773 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.8855 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.584 | 0.6194 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.584 | 0.6194 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.218 | 0.218 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0067 | 0.2456 | 0.1922 |
Brugia malayi | amidase | 0.0123 | 0.584 | 0.584 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0067 | 0.2456 | 0.1922 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0067 | 0.2456 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0177 | 0.9099 | 0.9099 |
Brugia malayi | bHLH-PAS transcription factor | 0.0042 | 0.0933 | 0.0933 |
Brugia malayi | hypoxia-induced factor 1 | 0.0177 | 0.9099 | 0.9099 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.8855 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.8855 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.8855 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.0736 | 0.0736 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0067 | 0.2456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.584 | 0.6194 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.584 | 1 |
Brugia malayi | Lipase family protein | 0.0173 | 0.8855 | 0.8855 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.8855 | 1 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.8855 | 0.8855 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.584 | 0.584 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0067 | 0.2456 | 0.2456 |
Onchocerca volvulus | 0.0173 | 0.8855 | 1 | |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.8855 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0067 | 0.2456 | 0.1552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay | ChEMBL. | 26584396 |
Ki (binding) | = 2000 nM | Inhibition of rat FAAH expressed in Escherichia coli at pH 9.0 | ChEMBL. | 18630870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.