Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.375 | 0.375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.453 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0687 | 0.1516 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0687 | 0.1516 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0687 | 0.1516 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.453 | 0.453 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.453 | 0.453 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.375 | 0.375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.453 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.453 | 0.453 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0687 | 0.1516 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.453 | 0.453 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.453 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.453 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0687 | 0.1516 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.375 | 0.375 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2332 | 0.2332 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.2332 | 0.2332 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.375 | 0.375 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.453 | 0.453 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.1516 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.453 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.453 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.1516 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2332 | 0.5147 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.1516 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0687 | 0.1516 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.453 | 0.453 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.453 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 44.7 % | Analgesic activity in Swiss albino mouse assessed as inhibition of acetic acid-induced writhing at 100 mg/kg, po administered 60 mins before acetic acid challenge after 5 to 15 mins relative to control | ChEMBL. | 17945398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.