Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0234 | 0.0726 | 0.5 |
Echinococcus granulosus | presenilin enhancer 2 | 0.022 | 0.0657 | 0.0512 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2178 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0849 | 0.3658 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2178 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.022 | 0.0657 | 0.0657 |
Brugia malayi | Presenilin family protein | 0.0234 | 0.0726 | 0.0726 |
Echinococcus granulosus | presenilin | 0.0234 | 0.0726 | 0.0581 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0234 | 0.0726 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0234 | 0.0726 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0234 | 0.0726 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0234 | 0.0726 | 0.0581 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0153 | 0.0153 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0234 | 0.0726 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.022 | 0.0657 | 0.0657 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.022 | 0.0657 | 0.0512 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0849 | 0.3658 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0849 | 0.3658 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2178 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0082 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0153 | 0.0153 |
Echinococcus multilocularis | presenilin | 0.0234 | 0.0726 | 0.0581 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2178 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | ChEMBL. | 19147367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.