Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.6632 | 0.6632 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0418 | 0.0418 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0418 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0897 | 0.0897 |
Echinococcus granulosus | jun protein | 0.0172 | 0.6839 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0418 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.4606 | 0.4606 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.5426 | 0.7941 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0897 | 0.1312 |
Echinococcus granulosus | geminin | 0.0171 | 0.6833 | 0.9991 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.4606 | 0.4606 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0897 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0418 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0418 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0244 | 1 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0897 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0897 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0897 | 0.1313 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0021 | 0.0021 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0172 | 0.6839 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0897 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0418 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0172 | 0.6839 | 0.6839 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0418 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0897 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0897 | 0.1312 |
Echinococcus multilocularis | geminin | 0.0171 | 0.6833 | 0.9991 |
Schistosoma mansoni | jun-related protein | 0.0139 | 0.5426 | 0.7941 |
Brugia malayi | hypothetical protein | 0.0135 | 0.5219 | 0.5219 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6833 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0418 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.4606 | 0.4606 |
Echinococcus multilocularis | jun protein | 0.0172 | 0.6839 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0172 | 0.6839 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6833 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0244 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.