Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melatonin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | melatonin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melatonin receptor 1B | 362 aa | 329 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.7748 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0334 | 0.7748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.4267 | 0.5371 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0227 | 0.0227 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0403 | 1 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.0206 | 0.352 | 0.352 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0184 | 0.2788 | 0.3406 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.264 | 0.264 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.4267 | 0.4267 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0106 | 0.0227 | 0.0227 |
Echinococcus multilocularis | GPCR, family 2 | 0.0106 | 0.0227 | 0.0227 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0106 | 0.0227 | 0.0227 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0228 | 0.4267 | 0.5371 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0106 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0334 | 0.7748 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0106 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0184 | 0.2788 | 0.3406 |
Echinococcus multilocularis | kinesin family 1 | 0.0206 | 0.352 | 0.352 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0227 | 0.0227 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0403 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0184 | 0.2788 | 0.3406 |
Echinococcus granulosus | GPCR family 2 | 0.0106 | 0.0227 | 0.0227 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0227 | 0.0227 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0334 | 0.7748 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0227 | 0.0227 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.86 nM | Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells | ChEMBL. | 18778943 |
Ki (binding) | = 5.9 nM | Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells | ChEMBL. | 18778943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.