Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.4483 | 0.8848 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.202 | 0.202 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0483 | 0.0953 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0378 | 0.0746 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1995 | 0.1995 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0483 | 0.0953 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.4483 | 0.4483 |
Trypanosoma brucei | squalene synthase, putative | 0.0286 | 0.9422 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0378 | 0.5 |
Leishmania major | squalene synthase, putative | 0.0286 | 0.9422 | 1 |
Echinococcus granulosus | geminin | 0.017 | 0.5067 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0286 | 0.9422 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.202 | 0.3987 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0089 | 0.202 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 0.5067 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0286 | 0.9422 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1546 | 0.3052 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0301 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.4483 | 0.8848 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0483 | 0.0483 |
Brugia malayi | hypothetical protein | 0.0088 | 0.1995 | 0.1995 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0089 | 0.202 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.2878 | 0.2878 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.0235 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1546 | 0.1546 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.5067 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0483 | 0.0953 |
Schistosoma mansoni | eyes absent homolog | 0.0088 | 0.1995 | 0.3938 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0483 | 0.0953 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.0235 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.5067 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1546 | 0.1546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0483 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1995 | 0.1995 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.015 | 0.432 | 0.8526 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0483 | 0.0953 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0483 | 0.0953 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0089 | 0.202 | 0.3987 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.0235 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.2878 | 0.2878 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0089 | 0.202 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0378 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0378 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.2878 | 0.2878 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2878 | 0.2878 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0378 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.4483 | 0.4483 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0089 | 0.202 | 0.3987 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0378 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.