Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.5 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.5 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.5 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0292 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.5 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.5 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to 5HT2b receptor at 500 nM to 2 uM | ChEMBL. | 18954981 | |
IC50 (binding) | = 7 nM | Inhibition of norepinephrine uptake at human NET transfected in HEK cells | ChEMBL. | 18954981 |
IC50 (binding) | = 200 nM | Inhibition of serotonin uptake at human SERT transfected in HEK cells | ChEMBL. | 18954981 |
IC50 (ADMET) | = 1000 nM | Inhibition of CYP2D6 | ChEMBL. | 18954981 |
IC50 (binding) | > 10000 nM | Inhibition of dopamine uptake at human DAT transfected in HEK cells | ChEMBL. | 18954981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.