Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0572 | 0.0572 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0593 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0414 | 0.6988 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0483 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0414 | 0.6988 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0593 | 0.0593 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2028 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0414 | 0.0981 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0483 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0414 | 0.0857 | |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0593 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0391 | 0.0391 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.5676 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2028 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2028 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0414 | 0.0414 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0414 | 0.6988 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0572 | 0.1354 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0414 | 0.0414 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.5676 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.4224 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0593 | 0.1404 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0414 | 0.0414 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.4224 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.5676 | 1 |
Onchocerca volvulus | 0.0239 | 0.4838 | 1 | |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0483 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.5676 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.5676 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.5676 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0572 | 0.0572 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0572 | 0.9643 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.5676 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0593 | 0.034 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.4838 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0572 | 0.9643 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.5676 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0593 | 0.1404 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2028 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0414 | 0.0981 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.5676 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0593 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0593 | 0.0593 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2028 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0414 | 0.6988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibition of Escherichia coli nickel containing peptide deformylase | ChEMBL. | 21621999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.