Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA topoisomerase IB, large subunit | 0.0169 | 0.1761 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.13 | 0.5147 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0169 | 0.1761 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0169 | 0.1761 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.024 | 0.0952 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.13 | 0.5147 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.024 | 0.0952 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0781 | 1 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0226 | 0.2526 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0226 | 0.2526 | 0.5 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0226 | 0.2526 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0781 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.1761 | 0.1761 |
Plasmodium falciparum | topoisomerase I | 0.0226 | 0.2526 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0226 | 0.2526 | 0.2526 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.024 | 0.0952 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.2526 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.13 | 0.5147 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.1761 | 0.1761 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.024 | 0.0952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 6.24 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
GI50 (functional) | = 0.5 uM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
GI50 (functional) | = 0.57 uM | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
GI50 (ADMET) | = 1.47 uM | Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
GI50 (functional) | = 2.43 uM | Cytotoxicity against human SAS cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
GI50 (functional) | = 3.37 uM | Cytotoxicity against human PC3 cells after 48 hrs by MTT assay | ChEMBL. | 20662543 |
IC50 (binding) | = 12.8 uM | Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis | ChEMBL. | 20662543 |
Inhibition (binding) | = 48 % | Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel at 10 uM by electrophoresis | ChEMBL. | 20662543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.