Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.6183 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.2153 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.2153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5313 | 0.8593 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.5313 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.6183 | 0.6183 |
Schistosoma mansoni | lamin | 0.0029 | 0.6183 | 0.5136 |
Echinococcus multilocularis | musashi | 0.0029 | 0.6183 | 0.5136 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.2153 | 0.3482 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.6183 | 0.5136 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.5313 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0902 | 0.0902 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.2153 | 0.5 |
Echinococcus granulosus | lamin | 0.0029 | 0.6183 | 0.5136 |
Echinococcus multilocularis | lamin | 0.0029 | 0.6183 | 0.5136 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.5313 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.2153 | 0.2153 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.6183 | 0.5136 |
Onchocerca volvulus | 0.0029 | 0.6183 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.6183 | 0.5136 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.5313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.5939 | 0.9606 |
Schistosoma mansoni | lamin | 0.0029 | 0.6183 | 0.5136 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2153 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.5313 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.2153 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.5313 | 0.5313 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2153 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.6183 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.5313 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.6183 | 0.5136 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.5313 | 1 |
Onchocerca volvulus | 0.0029 | 0.6183 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.6183 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.6183 | 0.6183 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.2153 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.5313 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.