Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0029 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2599 | 0.3397 |
Onchocerca volvulus | 0.0029 | 0.2706 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.2706 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.2706 | 0.3537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.4242 | 0.5545 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0287 | 0.0375 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.2706 | 0.3537 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.2706 | 0.3537 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 1 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.2706 | 0.3537 |
Schistosoma mansoni | lamin | 0.0029 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2706 | 0.3537 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.7651 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.7651 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0287 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4242 | 0.5545 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.2706 | 0.2491 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0029 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.0375 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0287 | 0.0375 |
Echinococcus granulosus | lamin | 0.0029 | 0.2706 | 0.2491 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.2706 | 0.2491 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.2706 | 0.2491 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.7651 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4242 | 0.4073 |
Echinococcus multilocularis | musashi | 0.0029 | 0.2706 | 0.2491 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 52 uM | Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methyl-coumarin as substrate measured every 30 secs for 10 mins by fluorescence microplate reader | ChEMBL. | 21741848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.