Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.019 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.2035 | 0.2035 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.019 | 1 | 1 |
Plasmodium vivax | protease, putative | 0.0039 | 0.1316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.4685 | 0.4685 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0039 | 0.1316 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.019 | 1 | 0.5 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0039 | 0.1316 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.019 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.2035 | 0.2035 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1093 | 0.1093 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0098 | 0.4685 | 0.4685 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2035 | 0.2035 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.019 | 1 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.019 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.019 | 1 | 0.5 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.019 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.6267 | 0.6267 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.6267 | 0.6267 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.019 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0098 | 0.4685 | 0.4685 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1093 | 0.1093 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0039 | 0.1316 | 0.5 |
Plasmodium falciparum | protease, putative | 0.0039 | 0.1316 | 0.5 |
Onchocerca volvulus | 0.0098 | 0.4685 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.2035 | 0.2035 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.6267 | 0.6267 |
Mycobacterium ulcerans | integral membrane protein | 0.0039 | 0.1316 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.019 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0098 | 0.4685 | 0.4685 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1093 | 0.1093 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0039 | 0.1316 | 0.5 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0039 | 0.1316 | 0.5 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.019 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.4685 | 0.4685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.