Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase | 0.0406 | 0.5093 | 0.5093 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0095 | 0.0187 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0322 | 0.0632 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0214 | 0.2622 | 0.5148 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0071 | 0.0083 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0496 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.36 | 0.7069 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0214 | 0.2622 | 0.5148 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0071 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0299 | 0.0588 |
Brugia malayi | cell division control protein 2 homolog | 0.0406 | 0.5093 | 1 |
Onchocerca volvulus | 0.0023 | 0.017 | 0.0648 | |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0214 | 0.2622 | 0.2622 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.017 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2213 | 0.4345 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0406 | 0.5093 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0214 | 0.2622 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0406 | 0.5093 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0071 | 0.0139 |
Brugia malayi | Muscleblind-like protein | 0.029 | 0.36 | 0.7069 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0406 | 0.5093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0095 | 0.0187 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0214 | 0.2622 | 0.3088 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0406 | 0.5093 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0406 | 0.5093 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.017 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0406 | 0.5093 | 0.5093 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0095 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0406 | 0.5093 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0406 | 0.5093 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.017 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.029 | 0.36 | 0.424 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0071 | 0.0139 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0322 | 0.0309 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0071 | 0.0083 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0406 | 0.5093 | 0.5998 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0406 | 0.5093 | 0.5998 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0406 | 0.5093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.017 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0095 | 0.0187 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0496 | 0.0974 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.4096 | 0.4824 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0071 | 0.0071 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0322 | 0.0379 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.4096 | 0.4824 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0071 | 0.0071 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0406 | 0.5093 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0071 | 0.0083 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.017 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0406 | 0.5093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0095 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.4451 | 0.8738 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0322 | 0.0379 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0496 | 0.0974 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0071 | 0.0139 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0406 | 0.5093 | 0.5998 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 0.4451 | 0.8695 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0214 | 0.2622 | 0.3088 |
Echinococcus granulosus | geminin | 0.0328 | 0.4096 | 0.4824 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0406 | 0.5093 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0406 | 0.5093 | 0.5093 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0406 | 0.5093 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0356 | 0.4451 | 0.8738 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0406 | 0.5093 | 0.5998 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0071 | 0.0083 |
Giardia lamblia | Kinase, CMGC CDK | 0.0406 | 0.5093 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.029 | 0.36 | 0.36 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0406 | 0.5093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0496 | 0.0974 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0071 | 0.0083 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.017 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.017 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0322 | 0.0309 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.017 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.067 | 0.8491 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.067 | 0.8491 | 0.8491 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.017 | 0.0333 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0322 | 0.0309 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0406 | 0.5093 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.017 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0071 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.36 | 0.7069 |
Echinococcus multilocularis | geminin | 0.0328 | 0.4096 | 0.4096 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0406 | 0.5093 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0406 | 0.5093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.5037 | 0.9891 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0322 | 0.0309 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0299 | 0.0588 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0322 | 0.0379 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0406 | 0.5093 | 0.5998 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0071 | 0.0083 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.017 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0406 | 0.5093 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.029 | 0.36 | 0.36 |
Plasmodium falciparum | protein kinase 5 | 0.0406 | 0.5093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.017 | 0.0333 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0406 | 0.5093 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0095 | 0.139 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0071 | 0.0139 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0406 | 0.5093 | 0.5093 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0299 | 0.0353 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.017 | 0.0333 |
Echinococcus granulosus | cyclin dependent kinase | 0.0406 | 0.5093 | 0.5998 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0095 | 0.0187 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0406 | 0.5093 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0406 | 0.5093 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.017 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.067 | 0.8491 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.017 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.017 | 0.0333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 2590 uM | Cytotoxicity against HepG2 2.2.15 cells | ChEMBL. | 17074481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.