pI: 5.9135 |
Length (AA): 528 |
MW (Da): 58949 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
55 | 255 | 4uvm (A) | 14 | 213 | 16.00 | 0.00011 | 0.15 | 0.506782 | -0.08 |
100 | 260 | 3wdo (A) | 52 | 204 | 28.00 | 0.000029 | 0.48 | 0.483524 | 0.75 |
102 | 452 | 3wdo (A) | 50 | 390 | 17.00 | 0 | 0.76 | 0.818073 | 0.5 |
192 | 432 | 1ldf (A) | 8 | 254 | 17.00 | 0 | 0.03 | 0.542739 | 0.23 |
445 | 512 | 4c47 (A) | 30 | 97 | 10.00 | 0 | 0 | 0.276088 | -0.61 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_133283)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_31305 | vesicular acetylcholine transporter unc-17 |
Caenorhabditis elegans | unc-17 | Protein UNC-17, isoform A |
Drosophila melanogaster | Dmel_CG32848 | CG32848 gene product from transcript CG32848-RA |
Echinococcus granulosus | EgrG_000706700 | vesicular acetylcholine transporter |
Echinococcus multilocularis | EmuJ_000706700 | vesicular acetylcholine transporter |
Homo sapiens | ENSG00000187714 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 |
Loa Loa (eye worm) | LOAG_10670 | vesicular acetylcholine transporter unc-17 |
Mus musculus | ENSMUSG00000100241 | solute carrier family 18 (vesicular monoamine), member 3 |
Onchocerca volvulus | OVOC3879 | Vesicular acetylcholine transporter homolog |
Schistosoma japonicum | Sjp_0301330 | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative |
Schistosoma mansoni | Smp_046120 | vesicular acetylcholine transporter |
Schmidtea mediterranea | mk4.003582.00 | |
Schmidtea mediterranea | mk4.000911.00 | |
Schmidtea mediterranea | mk4.004733.03 | |
Schmidtea mediterranea | mk4.001642.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Torpedo californica | Vesicular acetylcholine transporter | Compounds | References |
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Compounds | References |
Rattus norvegicus | Vesicular acetylcholine transporter | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Synaptic vesicular amine transporter | 517 aa | 36.8% | 517 aa | Compounds | References |
Rattus norvegicus | Synaptic vesicular amine transporter | 515 aa | 38.0% | 471 aa | Compounds | References |