Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0051 | 0.14 | 0.3271 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0014 | 0.0363 | 0.0363 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.1666 | 0.4112 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0051 | 0.14 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0014 | 0.0363 | 0.0363 |
Echinococcus granulosus | prolyl endopeptidase | 0.0129 | 0.3532 | 0.3532 |
Schistosoma mansoni | tsg101-related | 0.0249 | 0.68 | 0.8167 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0051 | 0.14 | 0.3271 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0014 | 0.0363 | 0.0363 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0093 | 0.2535 | 0.2535 |
Trypanosoma brucei | Vps23 core domain containing protein, putative | 0.0117 | 0.3193 | 0.893 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.3193 | 0.893 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0014 | 0.0363 | 0.0436 |
Trypanosoma cruzi | oligopeptidase b | 0.0051 | 0.14 | 0.3271 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Echinococcus multilocularis | tumor susceptibility gene 101 protein | 0.0366 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.1666 | 0.4112 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0014 | 0.0363 | 0.0363 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0129 | 0.3532 | 0.4242 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0116 | 0.316 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0129 | 0.3532 | 1 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0014 | 0.0363 | 0.0363 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0014 | 0.0363 | 0.0436 |
Leishmania major | oligopeptidase b | 0.0051 | 0.14 | 0.3271 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0014 | 0.0363 | 0.0363 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0093 | 0.2535 | 0.2535 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0014 | 0.0363 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.1666 | 0.2024 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0051 | 0.14 | 0.3271 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0363 | 0.0363 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0129 | 0.3532 | 0.4242 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0093 | 0.2535 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.3532 | 0.3532 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0014 | 0.0363 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0014 | 0.0363 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0129 | 0.3532 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0093 | 0.2535 | 0.2535 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0129 | 0.3532 | 0.3532 |
Toxoplasma gondii | prolyl endopeptidase | 0.0129 | 0.3532 | 1 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0014 | 0.0363 | 0.0363 |
Echinococcus granulosus | tumor susceptibility gene 101 protein | 0.0366 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0178 | 0.4867 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0051 | 0.14 | 0.3271 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0014 | 0.0363 | 0.0363 |
Schistosoma mansoni | tsg101-related | 0.0304 | 0.8326 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0093 | 0.2535 | 0.2535 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.1666 | 0.2024 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0014 | 0.0363 | 0.0436 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.1666 | 0.2024 |
Trypanosoma cruzi | oligopeptidase b | 0.0051 | 0.14 | 0.3271 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0014 | 0.0363 | 0.0363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.1666 | 0.2893 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0014 | 0.0363 | 0.0363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.1666 | 0.2893 |
Trypanosoma brucei | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Schistosoma mansoni | tsg101-related | 0.0304 | 0.8326 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0014 | 0.0363 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0129 | 0.3532 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0129 | 0.3532 | 0.3532 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0093 | 0.2543 | 0.2543 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0014 | 0.0363 | 0.0436 |
Trypanosoma cruzi | Vps23 core domain containing protein, putative | 0.0117 | 0.3193 | 0.893 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0014 | 0.0363 | 0.0363 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Trypanosoma cruzi | UEV domain/Zinc finger, C3HC4 type (RING finger), putative | 0.0061 | 0.1666 | 0.4112 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0051 | 0.14 | 0.3271 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0014 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0363 | 0.0363 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.1666 | 0.2024 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0051 | 0.14 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0051 | 0.14 | 0.3271 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0129 | 0.3532 | 1 |
Entamoeba histolytica | tumor susceptibility gene 101 protein, putative | 0.0249 | 0.68 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.2543 | 0.3054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ka (binding) | = 0.21 uM | In vitro binding affinity against human carbonic anhydrase I (hCA-I human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 0.21 uM | In vitro binding affinity against human carbonic anhydrase I (hCA-I human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 5 uM | In vitro inhibitory activity against bovine carbonic anhydrase IV (bCA IV) purified from lung microsomes. | ChEMBL. | 10450978 |
Ka (binding) | = 5 uM | In vitro inhibitory activity against bovine carbonic anhydrase IV (bCA IV) purified from lung microsomes. | ChEMBL. | 10450978 |
Ka (binding) | = 30 uM | In vitro binding affinity against human carbonic anhydrase II (hCA-II human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 30 uM | In vitro binding affinity against human carbonic anhydrase II (hCA-II human cloned isozyme). | ChEMBL. | 10450978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.