Detailed information for compound 103703

Basic information

Technical information
  • TDR Targets ID: 103703
  • Name: 6-(2,6-dimethylpyridin-3-yl)-8-propan-2-yl-1H -quinolin-2-one
  • MW: 292.375 | Formula: C19H20N2O
  • H donors: 1 H acceptors: 3 LogP: 4.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(n1)C)c1cc2ccc(nc2c(c1)C(C)C)O
  • InChi: 1S/C19H20N2O/c1-11(2)17-10-15(16-7-5-12(3)20-13(16)4)9-14-6-8-18(22)21-19(14)17/h5-11H,1-4H3,(H,21,22)
  • InChiKey: LQWJTWBVIRQSAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2,6-dimethyl-3-pyridyl)-8-isopropyl-1H-quinolin-2-one
  • 6-(2,6-dimethyl-3-pyridyl)-8-isopropyl-carbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0042 1 0.5
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0042 1 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0042 0.9642 0.8895
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0042 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0042 1 1
Giardia lamblia Kinase, AGC PKA 0.0042 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0042 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0042 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 1 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0042 0.9642 0.8895
Leishmania major protein kinase A catalytic subunit isoform 1 0.0042 1 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0042 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Onchocerca volvulus 0.0038 0.6761 0.5
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0042 1 1
Toxoplasma gondii AGC kinase 0.0042 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0042 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0042 1 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0042 1 1
Trichomonas vaginalis AGC family protein kinase 0.0042 1 1
Leishmania major protein kinase A catalytic subunit 0.0042 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0042 1 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0042 1 1
Toxoplasma gondii AGC kinase 0.0042 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0042 1 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0042 1 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0042 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0042 1 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0042 1 1

Activities

Activity type Activity value Assay description Source Reference
dP/dt (functional) = 16 % Inotropic activity measured as % increase in dP/dt maximum in Anesthetized dog at the dose of 50 microg/Kg administered intravenously ChEMBL. 2845085
Relative potency (functional) = 0.4 Percentage increase in dP/dt maximum observed with 4-[4-[2-(1,1-dioxo-2-isothiazolidinyl)-ethyl]-1-dimethoxyquinazoline (50 microg/Kg) in dog ChEMBL. 2845085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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