Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0482 | 0.5889 | 0.5 |
Echinococcus multilocularis | ras gtpase | 0.0482 | 0.5889 | 0.5889 |
Echinococcus granulosus | ras gtpase | 0.0482 | 0.5889 | 1 |
Entamoeba histolytica | ras-1, putative | 0.0482 | 0.5889 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | rap1 and, putative | 0.0482 | 0.5889 | 0.5 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0482 | 0.5889 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.5889 | 0.5 |
Trichomonas vaginalis | rheb, putative | 0.0482 | 0.5889 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0482 | 0.5889 | 1 |
Brugia malayi | Ras protein let-60 | 0.0482 | 0.5889 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0482 | 0.5889 | 0.5 |
Trichomonas vaginalis | dexras1, putative | 0.0482 | 0.5889 | 0.5 |
Trichomonas vaginalis | ral, putative | 0.0482 | 0.5889 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0 | 0.5 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0482 | 0.5889 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.0482 | 0.5889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Analgesic activity was measured using mouse anti-writhing method expressed as ED50 (po) | ChEMBL. | 7241504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.