Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | expressed protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma japonicum | ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0056 | 0.0129 | 0.0178 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.1113 | 0.7642 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0056 | 0.0129 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0423 | 0.1457 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0056 | 0.0129 | 0.0885 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0056 | 0.0129 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0056 | 0.0129 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0056 | 0.0129 | 0.0885 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0097 | 0.0668 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0097 | 0.0668 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0761 | 0.2678 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0056 | 0.0129 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0097 | 0.0668 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0097 | 0.0668 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0097 | 0.0668 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0423 | 0.1457 | 0.201 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0101 | 0.069 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0761 | 0.2678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0101 | 0.069 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0423 | 0.1457 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2025 | 0.7249 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0056 | 0.0129 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0761 | 0.2678 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0056 | 0.0129 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0761 | 0.2678 | 1 |
Onchocerca volvulus | 0.0048 | 0.0101 | 0.0101 | |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.1113 | 0.7642 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0056 | 0.0129 | 0.0885 |
Schistosoma mansoni | ap endonuclease | 0.0056 | 0.0129 | 0.0885 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0097 | 0.0134 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0056 | 0.0129 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0097 | 0.0668 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0097 | 0.0668 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0423 | 0.1457 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0097 | 0.0668 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0056 | 0.0129 | 0.0885 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0423 | 0.1457 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0761 | 0.2678 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0761 | 0.2678 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0761 | 0.2678 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0761 | 0.2678 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 | Inhibition of PTP1B | ChEMBL. | 19385614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.