Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.328 | 0.3241 |
Schistosoma mansoni | plexin | 0.0012 | 0.0834 | 0.0782 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.328 | 0.3241 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.328 | 0.3241 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0009 | 0.0443 | 0.0388 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.2265 | 0.2221 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.328 | 0.3241 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.328 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 1 | 1 |
Echinococcus granulosus | semaphorin 1A | 0.0009 | 0.0443 | 0.0388 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.2265 | 0.2221 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Brugia malayi | plexin A | 0.0025 | 0.2265 | 0.2221 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0009 | 0.0443 | 0.0388 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 1 | 1 |
Schistosoma mansoni | semaphorin 5-related | 0.0009 | 0.0443 | 0.0388 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0834 | 0.0782 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.328 | 0.3241 |
Echinococcus granulosus | semaphorin 5B | 0.0009 | 0.0443 | 0.0388 |
Giardia lamblia | Kinase, PLK | 0.0092 | 1 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.0443 | 0.0388 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1829 | 0.1782 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.328 | 0.3241 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0021 | 0.1829 | 0.1782 | |
Schistosoma mansoni | kinase | 0.0047 | 0.4811 | 0.4781 |
Echinococcus multilocularis | semaphorin 5B | 0.0009 | 0.0443 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0009 | 0.0443 | 0.0388 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 1 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.1829 | 0.1782 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.328 | 0.3241 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0443 | 0.0388 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.328 | 1 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.2265 | 0.2221 |
Schistosoma mansoni | plexin | 0.0021 | 0.1829 | 0.1782 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0834 | 0.0782 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.328 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.328 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0009 | 0.0443 | 0.0388 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.328 | 0.3241 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0587 uM | Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method | ChEMBL. | 21812414 |
Ki (binding) | = 0.0352 uM | Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay | ChEMBL. | 21812414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.