pI: 7.6036 |
Length (AA): 2181 |
MW (Da): 241276 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 1080 | 5l56 (A) | 278 | 1152 | 28.00 | 0 | 1 | 0.36141 | 1.73 |
677 | 894 | 5lsp (A) | 526 | 713 | 34.00 | 0.0000000000066 | 1 | 0.0625542 | 1.08 |
739 | 830 | 1uad (C) | 19 | 95 | 29.00 | 0 | 1 | 0.275682 | -0.47 |
1256 | 2075 | 3ig3 (A) | 1248 | 1856 | 38.00 | 0 | 1 | 0.268974 | 0.78 |
1258 | 2068 | 4m8m (A) | 553 | 1135 | 33.00 | 0 | 1 | 0.181848 | 1.01 |
1543 | 1648 | 4e74 (A) | 1513 | 1598 | 43.00 | 0 | 0.91 | 0.214102 | 0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127010)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_38550 | plexin A |
Caenorhabditis elegans | CELE_K04B12.1 | Protein PLX-2 |
Caenorhabditis elegans | CELE_Y55F3AL.1 | Protein PLX-1 |
Drosophila melanogaster | Dmel_CG17245 | Plexin B |
Drosophila melanogaster | Dmel_CG11081 | Plexin A |
Echinococcus granulosus | EgrG_000810300 | plexin a4 |
Echinococcus multilocularis | EmuJ_000810300 | plexin a4 |
Homo sapiens | ENSG00000196576 | plexin B2 |
Homo sapiens | ENSG00000221866 | plexin A4 |
Homo sapiens | ENSG00000004399 | plexin D1 |
Homo sapiens | ENSG00000130827 | plexin A3 |
Homo sapiens | ENSG00000164050 | plexin B1 |
Homo sapiens | ENSG00000114554 | plexin A1 |
Homo sapiens | ENSG00000198753 | plexin B3 |
Homo sapiens | ENSG00000076356 | plexin A2 |
Loa Loa (eye worm) | LOAG_08397 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13957 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11202 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01783 | plexin A |
Loa Loa (eye worm) | LOAG_09653 | hypothetical protein |
Mus musculus | ENSMUSG00000053646 | plexin B1 |
Mus musculus | ENSMUSG00000031385 | plexin B3 |
Mus musculus | ENSMUSG00000030084 | plexin A1 |
Mus musculus | ENSMUSG00000029765 | plexin A4 |
Mus musculus | ENSMUSG00000030123 | plexin D1 |
Mus musculus | ENSMUSG00000036606 | plexin B2 |
Mus musculus | ENSMUSG00000026640 | plexin A2 |
Mus musculus | ENSMUSG00000031398 | plexin A3 |
Schistosoma japonicum | Sjp_0040950 | ko:K06820 plexin A, putative |
Schistosoma japonicum | Sjp_0311740 | expressed protein |
Schistosoma japonicum | Sjp_0040960 | ko:K06820 plexin A, putative |
Schistosoma mansoni | Smp_145420 | plexin |
Schmidtea mediterranea | mk4.001017.06 | |
Schmidtea mediterranea | mk4.001017.04 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.