Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase | 614 aa | 507 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0634 | 0.3533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.286 | 0.432 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.057 | 0.3152 | 0.5052 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.286 | 0.432 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.047 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.0258 | 0.039 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.1154 | 0.662 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0634 | 0.3533 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.1154 | 0.662 | 1 |
Brugia malayi | Matrixin family protein | 0.109 | 0.624 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1724 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0258 | 0.0258 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0258 | 0.0414 |
Brugia malayi | Matrixin family protein | 0.052 | 0.286 | 0.4583 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0258 | 0.0414 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1154 | 0.662 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0258 | 0.0258 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0166 | 1 |
Brugia malayi | Matrixin family protein | 0.052 | 0.286 | 0.4583 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.0526 |
Onchocerca volvulus | 0.052 | 0.286 | 0.432 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | matrixin family protein | 0.109 | 0.624 | 0.9425 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.047 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.0258 | 0.0258 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.047 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0634 | 0.3533 | 0.5662 |
Brugia malayi | Matrixin family protein | 0.052 | 0.286 | 0.4583 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.0258 | 0.0819 |
Onchocerca volvulus | Matrilysin homolog | 0.052 | 0.286 | 0.432 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.0526 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0258 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.3533 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.286 | 0.432 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.052 | 0.286 | 0.9073 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0166 | 0.047 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.0258 | 0.039 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0166 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0258 | 0.0258 |
Schistosoma mansoni | hypothetical protein | 0.057 | 0.3152 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.0258 | 0.0258 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0166 | 0.0166 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.052 | 0.286 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0258 | 0.039 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0634 | 0.3533 | 1 |
Brugia malayi | Matrixin family protein | 0.052 | 0.286 | 0.4583 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0212 | 0.1032 | 0.3273 |
Onchocerca volvulus | 0.057 | 0.3152 | 0.4762 | |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 180 nM | Inhibitory activity against acetylcholinesterase | ChEMBL. | 7490731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.