Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0877 | 1 | 1 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0877 | 1 | 1 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0877 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0877 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0055 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0055 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0055 | 0 | 0.5 |
Onchocerca volvulus | 0.0877 | 1 | 1 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0055 | 0 | 0.5 |
Giardia lamblia | Kinase, CDC7 | 0.0877 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0055 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0877 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0877 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0877 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0877 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -2 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.