Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0056 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0056 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0056 | 0.086 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0105 | 0.2688 | 0.2688 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0041 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0105 | 0.2688 | 1 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0056 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0056 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0274 | 0.1018 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Echinococcus granulosus | cathepsin l1 | 0.0056 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0041 | 0.0274 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0056 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0056 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin L homolog | 0.0056 | 0.086 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0041 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0056 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0056 | 0.086 | 1 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0056 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0274 | 0.1018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0105 | 0.2688 | 1 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine protease, putative | 0.0056 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin F homolog | 0.0056 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0056 | 0.086 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0105 | 0.2688 | 0.2688 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0056 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0105 | 0.2688 | 0.2482 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0041 | 0.0274 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cysteine protease | 0.0056 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0056 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0041 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | ctsf protein | 0.0056 | 0.086 | 0.0603 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0056 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0056 | 0.086 | 0.086 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0105 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0056 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | fibroinase | 0.0056 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0105 | 0.2688 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0056 | 0.086 | 0.086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to human dopamine D2L receptor expressed in HEK cells assessed as Elk-1 activation preincubated for 1 hrs measured after 20 to 24 hrs by PathDetect trans Elk-1 reporter gene assay | ChEMBL. | 21784633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.