Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | histone deacetylase, putative | 0.0847 | 0.5238 | 0.5303 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 0.7251 | 0.7342 |
Onchocerca volvulus | 0.0057 | 0.024 | 0.0957 | |
Plasmodium vivax | histone deacetylase 2, putative | 0.158 | 0.9876 | 1 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0986 | 0.0998 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.158 | 0.9876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.7375 | 0.7467 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0986 | 0.0998 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0121 | 0.0232 |
Echinococcus granulosus | histone deacetylase 8 | 0.0415 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.2502 | 0.2533 |
Echinococcus granulosus | histone deacetylase 7 | 0.158 | 0.9876 | 0.9876 |
Trypanosoma cruzi | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0139 | 0.014 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0415 | 0.2502 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0847 | 0.5238 | 0.5238 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.024 | 0.024 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0121 | 0.0232 |
Echinococcus granulosus | histone deacetylase 1 | 0.0847 | 0.5238 | 0.5238 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.024 | 0.0243 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0847 | 0.5238 | 0.5303 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0847 | 0.5238 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.158 | 0.9876 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0847 | 0.5238 | 0.5303 |
Echinococcus granulosus | histone deacetylase 6 | 0.158 | 0.9876 | 0.9876 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0415 | 0.2502 | 0.2533 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.158 | 0.9876 | 0.9876 |
Echinococcus multilocularis | histone deacetylase 6 | 0.16 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.158 | 0.9876 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0847 | 0.5238 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0415 | 0.2502 | 0.2502 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0847 | 0.5238 | 0.5238 |
Brugia malayi | Histone deacetylase 1 | 0.0847 | 0.5238 | 0.5303 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.158 | 0.9876 | 1 |
Onchocerca volvulus | 0.0175 | 0.0986 | 0.3941 | |
Brugia malayi | histone deacetylase 11 | 0.0415 | 0.2502 | 0.2533 |
Echinococcus granulosus | tumor protein p63 | 0.0392 | 0.2358 | 0.2358 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0847 | 0.5238 | 0.5303 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0847 | 0.5238 | 0.5303 |
Echinococcus multilocularis | tumor protein p63 | 0.0392 | 0.2358 | 0.2358 |
Plasmodium falciparum | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0415 | 0.2502 | 0.2533 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.0753 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0104 | 0.0105 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0415 | 0.2502 | 0.2533 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0847 | 0.5238 | 0.5303 |
Echinococcus multilocularis | histone deacetylase | 0.158 | 0.9876 | 0.9876 |
Schistosoma mansoni | histone deacetylase hda2 | 0.16 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.158 | 0.9876 | 0.9876 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0847 | 0.5238 | 0.5303 |
Schistosoma mansoni | histone deacetylase | 0.0847 | 0.5238 | 0.5238 |
Entamoeba histolytica | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0847 | 0.5238 | 0.5238 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0415 | 0.2502 | 0.2502 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0847 | 0.5238 | 0.5303 |
Trypanosoma brucei | histone deacetylase 2 | 0.0415 | 0.2502 | 0.2533 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0847 | 0.5238 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.158 | 0.9876 | 0.9876 |
Trypanosoma cruzi | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0415 | 0.2502 | 0.2533 |
Brugia malayi | Histone deacetylase family protein | 0.158 | 0.9876 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0847 | 0.5238 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0847 | 0.5238 | 0.5303 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.158 | 0.9876 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0163 | 0.0163 |
Plasmodium falciparum | histone deacetylase 1 | 0.0847 | 0.5238 | 0.5303 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0847 | 0.5238 | 0.5303 |
Giardia lamblia | Histone deacetylase | 0.0847 | 0.5238 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.158 | 0.9876 | 0.9876 |
Leishmania major | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Echinococcus granulosus | histone deacetylase | 0.158 | 0.9876 | 0.9876 |
Echinococcus multilocularis | histone deacetylase 7 | 0.158 | 0.9876 | 0.9876 |
Plasmodium vivax | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0139 | 0.0139 |
Leishmania major | histone deacetylase, putative | 0.0847 | 0.5238 | 0.5303 |
Echinococcus granulosus | histone deacetylase 6 | 0.158 | 0.9876 | 0.9876 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0415 | 0.2502 | 0.2533 |
Loa Loa (eye worm) | hypothetical protein | 0.0847 | 0.5238 | 0.5303 |
Trypanosoma brucei | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0415 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0139 | 0.014 |
Trypanosoma brucei | histone deacetylase 4 | 0.158 | 0.9876 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0415 | 0.2502 | 0.2533 |
Echinococcus granulosus | histone deacetylase 3 | 0.0847 | 0.5238 | 0.5238 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.0753 | 0.0762 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0139 | 0.0139 |
Trypanosoma brucei | histone deacetylase 1 | 0.0847 | 0.5238 | 0.5303 |
Plasmodium falciparum | histone deacetylase 2 | 0.158 | 0.9876 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.0753 | 0.0762 |
Leishmania major | histone deacetylase, putative | 0.158 | 0.9876 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.