Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0125 | 0.0541 | 0.1306 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1183 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.049 | 0.3809 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.049 | 0.3809 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.049 | 0.3809 | 0.3571 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0468 | 0.3611 | 0.3344 |
Onchocerca volvulus | 0.0198 | 0.1199 | 1 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0251 | 0.1672 | 0.031 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0222 | 0.1408 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0125 | 0.0541 | 0.2901 |
Echinococcus multilocularis | serotonin receptor | 0.0125 | 0.0541 | 0.2901 |
Leishmania major | carbonic anhydrase family protein, putative | 0.049 | 0.3809 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0541 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.049 | 0.3809 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0222 | 0.1408 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0198 | 0.1199 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.0186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0541 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0222 | 0.1408 | 0.3613 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1183 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0944 | 0.7863 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.0485 | 0.1158 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0125 | 0.0541 | 0.2901 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 ug ml-1 | Compound was evaluated for inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS/R strain; NA=not active | ChEMBL. | 10377214 |
EC50 (functional) | NA 0 ug ml-1 | Inhibitory activity against vaccinia virus (VV). | ChEMBL. | 10377214 |
EC50 (functional) | = 0.1 ug ml-1 | Inhibitory activity against murine sarcoma virus induced transformation of murine C3H/3T3 embryo fibroblasts | ChEMBL. | 10377214 |
EC50 (functional) | = 20 ug ml-1 | Inhibition of herpes simplex virus type 1 (HSV-1) F strain | ChEMBL. | 10377214 |
EC50 (functional) | = 20 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) McIntyre strain | ChEMBL. | 10377214 |
EC50 (functional) | = 27 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK-) 07/1 strain | ChEMBL. | 10377214 |
EC50 (functional) | = 27 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK-) 07/1 strain | ChEMBL. | 10377214 |
EC50 (functional) | = 28 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS strain | ChEMBL. | 10377214 |
EC50 (functional) | = 28 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS strain | ChEMBL. | 10377214 |
EC50 (functional) | = 40.9 ug ml-1 | Inhibitory activity of compound against human immunodeficiency virus type 1 (HIV-1) induced cytopathogenicity in MT-4 cells | ChEMBL. | 10377214 |
EC50 (functional) | = 50 ug ml-1 | Inhibitory activity against human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in MT-4 cells | ChEMBL. | 10377214 |
EC50 (functional) | = 60 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) OKA strain | ChEMBL. | 10377214 |
EC50 (functional) | = 60 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) OKA strain | ChEMBL. | 10377214 |
EC50 (functional) | = 70 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) KOS strain | ChEMBL. | 10377214 |
EC50 (functional) | = 70 ug ml-1 | Inhibitory activity against herpes simplex virus type 2 (HSV-2) Lyons strain | ChEMBL. | 10377214 |
EC50 (functional) | = 70 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) VMW 1837 strain | ChEMBL. | 10377214 |
EC50 (functional) | = 70 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) VMW 1837 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 100 ug ml-1 | Inhibitory activity against cytomegalovirus (CMV) AD 169 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 100 ug ml-1 | Inhibitory activity against cytomegalovirus (CMV) Davis strain | ChEMBL. | 10377214 |
EC50 (functional) | = 150 ug ml-1 | Inhibitory activity against herpes simplex virus type 2 (HSV-2) 196 strain | ChEMBL. | 10377214 |
EC50 (functional) | = 400 ug ml-1 | Inhibitory activity against herpes simplex virus type 2 (HSV-2) G strain | ChEMBL. | 10377214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.