Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0122 | 0.0597 | 0.0597 |
Brugia malayi | Matrixin family protein | 0.0452 | 0.2845 | 0.4548 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0057 | 0.0159 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.2845 | 0.4251 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0159 | 0.0254 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0551 | 0.3515 | 0.5619 |
Echinococcus multilocularis | adam 17 protease | 0.0194 | 0.1088 | 0.1088 |
Echinococcus granulosus | adam 17 protease | 0.0213 | 0.1219 | 0.1219 |
Onchocerca volvulus | 0.0502 | 0.3182 | 0.0898 | |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0452 | 0.2845 | 0.4251 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.0568 | 0.0568 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0551 | 0.3515 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0225 | 0.1298 | 0.4079 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0091 | 0.0393 | 0.1235 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.0568 | 0.1785 |
Schistosoma mansoni | hypothetical protein | 0.0502 | 0.3182 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1003 | 0.659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.3515 | 0.528 |
Loa Loa (eye worm) | matrixin family protein | 0.0954 | 0.6256 | 0.9488 |
Loa Loa (eye worm) | matrixin family protein | 0.1003 | 0.659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.2845 | 0.4251 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.0159 | 0.0499 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0122 | 0.0597 | 0.0597 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0551 | 0.3515 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.2845 | 0.4251 |
Brugia malayi | Hemopexin family protein | 0.0502 | 0.3182 | 0.5086 |
Brugia malayi | Matrixin family protein | 0.0452 | 0.2845 | 0.4548 |
Mycobacterium ulcerans | hydrolase | 0.0551 | 0.3515 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0452 | 0.2845 | 0.8943 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0091 | 0.0393 | 0.0393 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.0077 | 0.0123 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0091 | 0.0393 | 0.0628 |
Brugia malayi | Matrixin family protein | 0.0954 | 0.6256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2538 | 0.3779 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0091 | 0.0393 | 0.0393 |
Onchocerca volvulus | Matrilysin homolog | 0.1003 | 0.659 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0159 | 0.0159 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0194 | 0.1088 | 0.3419 |
Brugia malayi | Matrixin family protein | 0.0452 | 0.2845 | 0.4548 |
Brugia malayi | Matrixin family protein | 0.0452 | 0.2845 | 0.4548 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.0133 | 0.0086 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0159 | 0.0159 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.0328 | 0.1031 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1504 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.0568 | 0.0568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Co (functional) | = 15 g dl-1 | Affinity towards oxygen by hemoglobin after modification by compound | ChEMBL. | 12620071 |
Co (functional) | = 15.13 g dl-1 | Affinity towards oxygen by hemoglobin after modification by compound | ChEMBL. | 12620071 |
Co (functional) | = 15.92 g dl-1 | Affinity towards oxygen by hemoglobin after modification by compound | ChEMBL. | 12620071 |
Csat (functional) | = 19.08 g dl-1 | Inhibition of sickle hemoglobin aggregation using standard saturation solubility (CSAT) assay | ChEMBL. | 12620071 |
Csat (functional) | = 19.73 g dl-1 | Inhibition of sickle hemoglobin aggregation using standard saturation solubility (CSAT) assay | ChEMBL. | 12620071 |
Csat (functional) | = 20.69 g dl-1 | Inhibition of sickle hemoglobin aggregation using standard saturation solubility (CSAT) assay | ChEMBL. | 12620071 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.