Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0676 | 0.3877 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1685 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0144 | 0.0649 | 0.5 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0144 | 0.0649 | 0.0594 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0144 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1041 | 0.1041 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0676 | 0.3877 | 0.3856 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0676 | 0.3877 | 0.3856 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0144 | 0.0649 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0144 | 0.0649 | 0.0617 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0676 | 0.3877 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0144 | 0.0649 | 0.5 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0144 | 0.0649 | 0.0617 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0676 | 0.3877 | 0.3841 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0144 | 0.0649 | 0.0617 |
Plasmodium falciparum | peptidase, putative | 0.0144 | 0.0649 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.0617 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0676 | 0.3877 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1685 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0676 | 0.3877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.0649 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0144 | 0.0649 | 0.0649 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0144 | 0.0649 | 0.0617 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1685 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0144 | 0.0649 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0144 | 0.0649 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0144 | 0.0649 | 0.0594 |
Mycobacterium tuberculosis | Probable peptidase | 0.0144 | 0.0649 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1685 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0676 | 0.3877 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0144 | 0.0649 | 0.0594 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0034 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0467 | 0.261 | 0.2585 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0144 | 0.0649 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0144 | 0.0649 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.261 | 0.261 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0144 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0649 | 0.0649 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.0617 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0144 | 0.0649 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0144 | 0.0649 | 0.0617 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0144 | 0.0649 | 0.0594 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0676 | 0.3877 | 0.3856 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1685 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0612 | 0.3485 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0649 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | mM | Reversible inhibition of Human AchE | ChEMBL. | 3746817 |
kn (binding) | M-1 min-1 | Bimolecular rate constant (kn) for reaction of the anionic (oximate) with 7.5 x 10 e-4 M acetylthiocholine (AcSCh) in 0.1 M phosphate buffer | ChEMBL. | 3746817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.