Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0002 | 0.0011 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.047 | 0.175 | 0.5 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.047 | 0.175 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.047 | 0.175 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0493 | 0.184 | 0.011 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.047 | 0.175 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.047 | 0.175 | 1 |
Onchocerca volvulus | 0.0028 | 0.0002 | 0.5 | |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.047 | 0.175 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0002 | 0.5 | |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.2558 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.047 | 0.175 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.047 | 0.175 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.047 | 0.175 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.047 | 0.175 | 0.5 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.047 | 0.175 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0002 | 0.0011 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.047 | 0.175 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0102 | 0.0572 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.047 | 0.175 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.047 | 0.175 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0002 | 0.0011 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.047 | 0.175 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | 0 % | Tested for in vivo inhibition of galactitol accumulation in the lens of galactose-fed rats at the dose of 54 (mg/kg/day); NS=Not significant | ChEMBL. | 8027987 |
Inhibition (functional) | 0 % | tTested for in vivo inhibition of galactitol accumulation in the sciatic nerve of galactose-fed rats at the dose of 54 (mg/kg/day); NS=Not significant | ChEMBL. | 8027987 |
Inhibition (binding) | = 68 % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10 e-6 M | ChEMBL. | 8027987 |
Inhibition (binding) | = 68 % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10 e-6 M | ChEMBL. | 8027987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.