Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0044 | 0.0356 | 0.3062 |
Entamoeba histolytica | protein kinase 2, putative | 0.0085 | 0.0781 | 0.5959 |
Schistosoma mansoni | protein kinase | 0.0121 | 0.1152 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus multilocularis | nervana 2 | 0.0084 | 0.0769 | 0.6667 |
Schistosoma mansoni | protein phosphatase 1 inhibitor potentiated by protein kinase C | 0.0028 | 0.0187 | 0.1595 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0137 | 0.131 | 0.1804 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0268 | 0.266 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0187 | 0.0253 |
Giardia lamblia | Telomerase catalytic subunit | 0.0268 | 0.266 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0268 | 0.266 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0268 | 0.266 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0712 | 0.7242 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0044 | 0.0356 | 0.0485 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0356 | 0.2715 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0268 | 0.266 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0128 | 0.1224 | 0.9335 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0268 | 0.266 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0094 | 0.0868 | 0.3262 |
Toxoplasma gondii | AGC kinase | 0.0128 | 0.1224 | 0.46 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | protein kinase | 0.0121 | 0.1152 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0268 | 0.266 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0094 | 0.0868 | 0.7525 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0044 | 0.0356 | 0.269 |
Schistosoma mansoni | serine/threonine kinase | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0121 | 0.1152 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0044 | 0.0356 | 0.3062 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0356 | 0.0485 |
Echinococcus multilocularis | nervana 2 | 0.0084 | 0.0769 | 0.6667 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0356 | 0.2715 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0356 | 0.2715 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0084 | 0.0769 | 0.6667 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | nervana 2 | 0.0084 | 0.0769 | 0.6667 |
Echinococcus granulosus | protein kinase c iota type | 0.0044 | 0.0356 | 0.3062 |
Echinococcus multilocularis | protein kinase c iota type | 0.0044 | 0.0356 | 0.3062 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0085 | 0.0781 | 0.2936 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0085 | 0.0781 | 0.6768 |
Entamoeba histolytica | protein kinase, putative | 0.0137 | 0.131 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0053 | 0.0443 | 0.3378 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0085 | 0.0781 | 0.6768 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | PKC activated phosphatase 1 inhibitor | 0.0028 | 0.0187 | 0.1595 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0044 | 0.0356 | 0.269 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0356 | 0.0485 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0043 | 0.0344 | 0.2627 |
Echinococcus multilocularis | PKC activated phosphatase 1 inhibitor | 0.0028 | 0.0187 | 0.1595 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0085 | 0.0781 | 0.6768 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | atypical protein kinase C | 0.0044 | 0.0356 | 0.3062 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0187 | 0.1401 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0094 | 0.0868 | 0.3262 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0137 | 0.131 | 0.4927 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0094 | 0.0868 | 0.7525 |
Echinococcus granulosus | nervana 2 | 0.0084 | 0.0769 | 0.6667 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0121 | 0.1152 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0044 | 0.0356 | 0.269 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0085 | 0.0781 | 0.2936 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0044 | 0.0356 | 0.269 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0084 | 0.0769 | 0.6667 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0044 | 0.0356 | 0.3062 |
Brugia malayi | protein kinase C II. | 0.0044 | 0.0356 | 0.0485 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0044 | 0.0356 | 0.3062 |
Echinococcus granulosus | NDR protein kinase | 0.0044 | 0.0356 | 0.3062 |
Entamoeba histolytica | protein kinase, putative | 0.0137 | 0.131 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0094 | 0.0868 | 0.7525 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0094 | 0.0868 | 0.6622 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0094 | 0.0868 | 0.6622 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0044 | 0.0356 | 0.269 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0044 | 0.0356 | 0.269 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0268 | 0.266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0356 | 0.269 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0094 | 0.0868 | 0.7525 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0044 | 0.0356 | 0.3062 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0128 | 0.1224 | 0.9337 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0044 | 0.0356 | 0.3062 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0128 | 0.1224 | 0.1684 |
Entamoeba histolytica | protein kinase, putative | 0.0044 | 0.0356 | 0.2715 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0137 | 0.131 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0084 | 0.0769 | 0.6667 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.131 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0084 | 0.0769 | 0.6667 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0085 | 0.0781 | 0.2936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.