Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0051 | 0.0283 | 0.0704 |
Schistosoma mansoni | lozenge | 0.0055 | 0.0362 | 0.0901 |
Onchocerca volvulus | 0.0134 | 0.1831 | 0.2141 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | bZIP transcription factor family protein | 0.0171 | 0.2513 | 0.2513 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0051 | 0.0283 | 0.0704 |
Loa Loa (eye worm) | runx1 | 0.0055 | 0.0362 | 0.0185 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0051 | 0.0283 | 0.0804 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0051 | 0.0283 | 0.0804 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0051 | 0.0283 | 0.0704 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0252 | 0.4012 | 1 |
Brugia malayi | steroid hormone receptor | 0.0051 | 0.0283 | 0.0283 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0457 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0051 | 0.0283 | 0.0104 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0051 | 0.0283 | 0.0704 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0171 | 0.2513 | 0.7155 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.7514 | 0.7468 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0051 | 0.0283 | 0.0283 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0457 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Onchocerca volvulus | 0.044 | 0.7514 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0051 | 0.0283 | 0.0104 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0051 | 0.0283 | 0.0804 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0051 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0051 | 0.0283 | 0.0104 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0051 | 0.0283 | 0.0704 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1831 | 0.1831 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0051 | 0.0283 | 0.0104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.018 | 0.0449 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0051 | 0.0283 | 0.0804 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0051 | 0.0283 | 0.0104 |
Schistosoma mansoni | coup transcription factor | 0.0051 | 0.0283 | 0.0704 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.7514 | 0.7468 |
Brugia malayi | nuclear hormone receptor | 0.0051 | 0.0283 | 0.0283 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0051 | 0.0283 | 0.0283 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0051 | 0.0283 | 0.0804 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0252 | 0.4012 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.018 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0051 | 0.0283 | 0.0804 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.018 | 0.018 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0051 | 0.0283 | 0.0283 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0051 | 0.0283 | 0.0283 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0051 | 0.0283 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2426 | 0.2287 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | ecdysteroid receptor | 0.0051 | 0.0283 | 0.0283 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.018 | 0.0449 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0051 | 0.0283 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Schistosoma mansoni | nuclear hormone receptor | 0.0051 | 0.0283 | 0.0704 |
Echinococcus multilocularis | Protein lozenge | 0.0055 | 0.0362 | 0.1029 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0171 | 0.2513 | 0.6263 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.0283 | 0.0704 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0051 | 0.0283 | 0.0804 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0051 | 0.0283 | 0.0283 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.018 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0051 | 0.0283 | 0.0104 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0457 | 0.1139 |
Echinococcus multilocularis | jun protein | 0.0171 | 0.2513 | 0.7155 |
Brugia malayi | hypothetical protein | 0.044 | 0.7514 | 0.7514 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0051 | 0.0283 | 0.0804 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0051 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0283 | 0.0104 |
Echinococcus granulosus | jun protein | 0.0171 | 0.2513 | 0.6263 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0051 | 0.0283 | 0.0283 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.1918 | 0.478 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.018 | 0.0449 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0051 | 0.0283 | 0.0104 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0051 | 0.0283 | 0.0704 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0457 | 0.1301 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0051 | 0.0283 | 0.0804 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.0283 | 0.0283 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.018 | 0.0449 |
Brugia malayi | nuclear receptor NHR-88 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.018 | 0.0513 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0051 | 0.0283 | 0.0704 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0457 | 0.1139 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0051 | 0.0283 | 0.0704 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0051 | 0.0283 | 0.0283 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0225 | 0.3512 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0051 | 0.0283 | 0.0704 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0051 | 0.0283 | 0.0104 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0051 | 0.0283 | 0.0283 |
Schistosoma mansoni | jun-related protein | 0.0139 | 0.1918 | 0.478 |
Echinococcus granulosus | FTZ F1 alpha | 0.0051 | 0.0283 | 0.0704 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.