Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 1 | 0.5 |
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 0.15 ug.hr/ml | AUC (0 to 8 hrs) in C57BL/6J mouse at 20 mg/kg, po measured up to 8 hrs | ChEMBL. | 19540759 |
AUC (ADMET) | = 24 ug.hr/ml | AUC (0 to 8 hrs) in C57BL/6J mouse at 5 mg/kg, iv measured up to 8 hrs | ChEMBL. | 19540759 |
CL (ADMET) | = 3.4 ml/min.kg | Clearance in C57BL/6J mouse at 5 mg/kg, iv measured up to 8 hrs | ChEMBL. | 19540759 |
Cmax (ADMET) | = 0.07 ug ml-1 | Cmax in C57BL/6J mouse at 20 mg/kg, po measured up to 8 hrs | ChEMBL. | 19540759 |
F (ADMET) | = 0.2 % | Oral bioavailability in C57BL/6J mouse at 20 mg/kg measured up to 8 hrs | ChEMBL. | 19540759 |
IC50 (binding) | = 3 nM | Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins | ChEMBL. | 19540759 |
IC50 (binding) | = 10 nM | Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins | ChEMBL. | 19540759 |
Inhibition (binding) | = 16 % | Inhibition of delta-6 desaturase in human microsomes assessed as conversion of [14C]linolenic acid to [14C]stearidonic acid at 10 uM | ChEMBL. | 19540759 |
T1/2 (ADMET) | = 1.3 hr | Half life in C57BL/6J mouse at 20 mg/kg, po measured up to 8 hrs | ChEMBL. | 19540759 |
T1/2 (ADMET) | = 1.4 hr | Half life in C57BL/6J mouse at 5 mg/kg | ChEMBL. | 19540759 |
Tmax (ADMET) | = 0.5 hr | Tmax in C57BL/6J mouse at 20 mg/kg, po measured up to 8 hrs | ChEMBL. | 19540759 |
Vd (ADMET) | = 0.42 L/Kg | Volume of distribution in C57BL/6J mouse at 5 mg/kg, iv measured up to 8 hrs | ChEMBL. | 19540759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.