Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0186 | 0.2123 |
Brugia malayi | thymidylate synthase | 0.0159 | 0.0836 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 0.9554 |
Onchocerca volvulus | 0.0159 | 0.0836 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.0293 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0159 | 0.0836 | 0.9554 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0186 | 0.2123 |
Mycobacterium ulcerans | thymidylate synthase | 0.0159 | 0.0836 | 0.0662 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0186 | 0.2123 |
Echinococcus granulosus | geminin | 0.0165 | 0.0875 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0076 | 0.0293 | 0.0109 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0875 | 1 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1567 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0186 | 0.2123 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0836 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0159 | 0.0836 | 0.9554 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0159 | 0.0836 | 0.0662 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1567 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0875 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0875 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0293 | 0.3502 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0159 | 0.0836 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0836 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 146 nM | Binding affinity towards opioid receptor kappa was determined | ChEMBL. | 2567782 |
Ki (binding) | = 425 nM | Binding affinity towards opioid receptor mu was determined | ChEMBL. | 2567782 |
Ratio (binding) | = 3 | Ratio of binding affinity towards opioid receptor mu to that of opioid receptor kappa | ChEMBL. | 2567782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.