Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0795 | 0.2595 | 0.3945 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0672 | 0.216 | 0.216 |
Onchocerca volvulus | 0.1127 | 0.3769 | 0.6265 | |
Echinococcus granulosus | microtubule associated protein 2 | 0.0672 | 0.216 | 0.216 |
Brugia malayi | Matrixin family protein | 0.0795 | 0.2595 | 0.3945 |
Schistosoma mansoni | tyrosine kinase | 0.0133 | 0.0256 | 0.068 |
Mycobacterium ulcerans | hydrolase | 0.0968 | 0.3207 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0136 | 0.0267 | 0.0709 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0968 | 0.3207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0795 | 0.2595 | 0.3945 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0795 | 0.2595 | 0.3945 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1186 | 0.3976 | 0.3976 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0795 | 0.2595 | 0.6885 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0136 | 0.0267 | 0.0267 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0672 | 0.216 | 0.573 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0968 | 0.3207 | 0.4876 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.3207 | 0.4876 |
Brugia malayi | Hemopexin family protein | 0.1127 | 0.3769 | 0.573 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0968 | 0.3207 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.1763 | 0.6017 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1763 | 0.6017 | 0.9146 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1186 | 0.3976 | 0.3976 |
Brugia malayi | Matrixin family protein | 0.1922 | 0.6578 | 1 |
Brugia malayi | Matrixin family protein | 0.0795 | 0.2595 | 0.3945 |
Loa Loa (eye worm) | hypothetical protein | 0.0795 | 0.2595 | 0.3945 |
Brugia malayi | Matrixin family protein | 0.0795 | 0.2595 | 0.3945 |
Loa Loa (eye worm) | matrixin family protein | 0.1922 | 0.6578 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0795 | 0.2595 | 0.4313 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0212 | 0.0322 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0136 | 0.0267 | 0.0267 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.289 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0795 | 0.2595 | 0.3945 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0212 | 0.0322 |
Onchocerca volvulus | 0.0795 | 0.2595 | 0.4313 | |
Schistosoma mansoni | hypothetical protein | 0.1127 | 0.3769 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1763 | 0.6017 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0212 | 0.0322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 6.2 | DNA binding affinity measured as an increase in thermal melting of d(CGCGAATTCGCG)2 | ChEMBL. | 12781196 |
Delta Tm (binding) | = 15.4 | DNA binding affinity measured as an increase in thermal melting of poly(dA.dT)2 | ChEMBL. | 12781196 |
IC50 (functional) | = 14.5 uM | Inhibitory activity against Leishmania donovani (amastigote) | ChEMBL. | 12781196 |
IC50 (functional) | = 14.5 uM | Inhibitory activity against Leishmania donovani (amastigote) | ChEMBL. | 12781196 |
IC50 (functional) | > 29 uM | Inhibitory activity against Leishmania donovani (macrophage) | ChEMBL. | 12781196 |
IC50 (functional) | = 29 uM | Inhibitory activity against Trypanosoma cruzi | ChEMBL. | 12781196 |
IC50 (functional) | > 29 uM | Inhibitory activity against Leishmania donovani (macrophage) | ChEMBL. | 12781196 |
IC50 (functional) | = 29 uM | Inhibitory activity against Trypanosoma cruzi | ChEMBL. | 12781196 |
IC50 (functional) | = 39.6 uM | Cell toxicity of the compound was evaluated | ChEMBL. | 12781196 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 12781196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.