Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0139 | 0.0146 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3114 | 0.3273 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0139 | 0.0139 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0139 | 0.0139 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0139 | 0.0139 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0139 | 0.0139 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0139 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.9514 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3114 | 0.3114 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0139 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0139 | 0.0139 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0139 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0139 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3114 | 0.3273 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0139 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3114 | 0.3114 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0139 | 0.0146 |
Echinococcus multilocularis | geminin | 0.0187 | 1 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0139 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3114 | 0.3114 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3114 | 0.3273 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0139 | 0.0146 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3114 | 0.3273 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0139 | 0.0139 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0139 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3114 | 0.3114 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3114 | 0.3273 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0139 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0139 | 0.0139 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.0139 | 0.0146 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3114 | 0.3273 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3114 | 0.3114 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0139 | 0.0139 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3114 | 0.3114 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0139 | 0.0146 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.9514 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0139 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0139 | 0.0139 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.9514 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0139 | 0.0139 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0139 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3114 | 0.3114 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0139 | 0.0139 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0139 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.051 g | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor weight at 44.64 umol/kg/day, ip administered for 7 consecutive days after 24 hrs of tumor implantation measured after 24 hrs post dose | ChEMBL. | 19631550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.