Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.9524 | 0.977 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0649 | 0.9749 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0649 | 0.9749 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 13 mm | Antibacterial activity against Escherichia coli ATCC 35218 at 100 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | 19168262 |
IZ (functional) | = 15 mm | Antifungal activity against Candida albicans at 100 ug/ml after 72 hrs by agar well diffusion method | ChEMBL. | 19168262 |
MIC (functional) | = 3 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by agar well diffusion method | ChEMBL. | 19168262 |
MIC (functional) | = 3 ug ml-1 | Antifungal activity against Candida albicans after 72 hrs by agar well diffusion method | ChEMBL. | 19168262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.