Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.166 | 0.7923 | 0.6808 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1919 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1919 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1919 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.1159 | 0.3903 | 0.0629 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.166 | 0.7923 | 0.6808 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1159 | 0.3903 | 0.0629 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.166 | 0.7923 | 0.7178 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0802 | 0.1031 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.166 | 0.7923 | 0.6808 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1159 | 0.3903 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1919 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0761 | 0.0702 | 0.0702 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.166 | 0.7923 | 0.7178 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1919 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0802 | 0.1031 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.112 | 0.3592 | 0.0151 |
Giardia lamblia | Ceramide glucosyltransferase | 0.087 | 0.1579 | 0.5 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.166 | 0.7923 | 0.6808 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1919 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.15 ug ml-1 | Antibacterial activity against Staphylococcus aureus 011HT3 strain | ChEMBL. | 10450985 |
MIC (functional) | = 0.3 ug ml-1 | Antibacterial activity against ofloxacin, oxacillin and erythromycin resistant Staphylococcus aureus strain 011GO76 | ChEMBL. | 10450985 |
MIC (functional) | = 0.3 ug ml-1 | Antibacterial activity against oxacillin and teicoplanin resistant S. epidermidis 012GO39 strain | ChEMBL. | 10450985 |
MIC (functional) | = 1.2 ug ml-1 | Antibacterial activity against Streptococcus pyogenes 02A1UC1 strain | ChEMBL. | 10450985 |
MIC (functional) | = 10 ug ml-1 | Antibacterial activity against vancomycin, teicoplanin and erythromycin resistant Enterococcus faecium 02D31P2 strain | ChEMBL. | 10450985 |
MIC (functional) | = 40 ug ml-1 | Antibacterial activity against Staphylococcus aureus novobiocin resistant strain 011HT1 | ChEMBL. | 10450985 |
Ratio (binding) | = 2 | Ratio of IC50 compared to novobiocin in E. coli DNA gyrase supercoiling assay | ChEMBL. | 10450985 |
Ratio (binding) | = 2 | Ratio of IC50 compared to novobiocin in E. coli DNA gyrase supercoiling assay | ChEMBL. | 10450985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.