Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0279 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0258 | 0.8326 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0258 | 0.8326 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0258 | 0.8326 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.3233 | 0.1027 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0258 | 0.8326 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.3233 | 0.1027 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0258 | 0.8326 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0258 | 0.8326 | 0.8326 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24.4 uM | Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase | ChEMBL. | 12519058 |
IC50 (binding) | = 24.4 uM | Inhibitory concentration against thymidine phosphorylase of Escherichia coli | ChEMBL. | 15658853 |
IC50 (binding) | = 24.4 uM | Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase | ChEMBL. | 12519058 |
IC50 (binding) | = 24.4 uM | Inhibitory concentration against thymidine phosphorylase of Escherichia coli | ChEMBL. | 15658853 |
IC50 (binding) | = 160 uM | Inhibitory concentration against human thymidine phosphorylase | ChEMBL. | 15658853 |
IC50 (binding) | = 160 uM | Inhibitory concentration against human thymidine phosphorylase | ChEMBL. | 15658853 |
Km (binding) | = 23.9 uM | Michaelis-menton constant against xanthine oxidase under anaerobic conditions | ChEMBL. | 15658853 |
Km (binding) | = 92.4 uM | Michaelis-menton constant against xanthine oxidase under aerobic conditions | ChEMBL. | 15658853 |
Ratio (binding) | = 1284 | Inhibition selectivity ratio against Thymidine Phosphorylase is the ratio of IC50 of the nitro compound to the IC50 of amino compound | ChEMBL. | 12519058 |
Vmax (binding) | = 0.0057 delta A/min | Vmax against xanthine oxidase under aerobic conditions | ChEMBL. | 15658853 |
Vmax (binding) | = 0.0109 delta A/min | Vmax against xanthine oxidase under anaerobic conditions | ChEMBL. | 15658853 |
Vmax (binding) | = 0.373 uM/min | Vmax against xanthine oxidase under aerobic conditions | ChEMBL. | 15658853 |
Vmax (binding) | = 0.72 uM/min | Vmax against xanthine oxidase under anaerobic conditions | ChEMBL. | 15658853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.