Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 25A | Starlite/ChEMBL | References |
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Muscleblind-like protein | 0.0154 | 0.7766 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.7766 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0154 | 0.7766 | 0.7766 |
Onchocerca volvulus | 0.0137 | 0.632 | 0.5 | |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0137 | 0.632 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0137 | 0.632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.632 | 0.8138 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.7766 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0137 | 0.632 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0137 | 0.632 | 0.8138 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.0172 |
Onchocerca volvulus | 0.0137 | 0.632 | 0.5 | |
Echinococcus granulosus | muscleblind protein | 0.0154 | 0.7766 | 0.7766 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0172 | 0.0172 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.0172 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.5 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0137 | 0.632 | 0.632 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0137 | 0.632 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0137 | 0.632 | 0.8138 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0172 | 0.0172 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0.632 | 0.5 |
Onchocerca volvulus | 0.0137 | 0.632 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0.632 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0137 | 0.632 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.5 |
Onchocerca volvulus | 0.0137 | 0.632 | 0.5 | |
Trichomonas vaginalis | cdc25b, putative | 0.0137 | 0.632 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0137 | 0.632 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0172 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.632 | 0.8138 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0.632 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0137 | 0.632 | 0.632 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5412 | 0.6968 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0137 | 0.632 | 0.632 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0154 | 0.7766 | 0.7766 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0172 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5412 | 0.6968 |
Trichomonas vaginalis | cdc25b, putative | 0.0137 | 0.632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 uM | Inhibition of N-terminal 6xHis-tagged (378-566) catalytic domain of Cdc25B expressed in Escherichia coli after 20 mins by by fluorescent plate reader assay | ChEMBL. | 19497739 |
IC50 (binding) | = 17.2 uM | Inhibition of N-terminal 6xHis-tagged human Cdc25A (336-523) catalytic domain expressed in Escherichia coli after 20 mins by fluorescent plate reader assay | ChEMBL. | 19497739 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.