Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | pteridine reductase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Leishmania infantum | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Trypanosoma congolense | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Trypanosoma brucei | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania major | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania braziliensis | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania mexicana | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania donovani | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | pteridine reductase 1 | 288 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.001 | 0 | 0.5 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.001 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.001 | 0 | 0.5 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0071 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0448 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0013 | 0.0071 | 0.0137 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0071 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.001 | 0 | 0.5 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.001 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.001 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0238 | 0.5196 | 1 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0013 | 0.0071 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0013 | 0.0071 | 1 |
Chlamydia trachomatis | oxoacy-ACP reductase | 0.001 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0.0071 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0071 | 1 |
Onchocerca volvulus | 0.0013 | 0.0071 | 1 | |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0.0071 | 0.0138 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0013 | 0.0071 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0448 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0448 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0235 | 0.5125 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 uM | Inhibition of Leishmania major recombinant PTR1 | ChEMBL. | 19916554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.