Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.1349 | 1 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.1349 | 0.1349 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.1349 | 0.535 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.2149 | 0.2889 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.2522 | 0.4673 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.2149 | 0.2889 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.2839 | 0.2839 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.1349 | 0.1814 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.2522 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0037 | 0.2522 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0037 | 0.2522 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1349 | 0.25 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.2839 | 0.2839 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 1 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0037 | 0.2522 | 0.2522 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.2149 | 0.2149 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.1349 | 0.535 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 0.2522 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.1349 | 0.1349 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.2149 | 0.3982 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.5398 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0037 | 0.2522 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.1349 | 0.535 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.2522 | 1 |
Echinococcus granulosus | peregrin | 0.0029 | 0.1349 | 0.1349 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 0.2522 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.2522 | 0.2522 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.1349 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0037 | 0.2522 | 0.339 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.1349 | 0.1814 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.2522 | 0.4673 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.2522 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.1349 | 0.1349 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.1349 | 0.1349 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.1349 | 0.1349 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0037 | 0.2522 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 0.2522 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0037 | 0.2522 | 0.2522 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.7441 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0037 | 0.2522 | 0.2522 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.2149 | 0.2149 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.2149 | 0.2149 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.1349 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4066 | 0.7532 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.1349 | 0.535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.