Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0133 | 0.0753 | 0.0987 |
Chlamydia trachomatis | hypothetical protein | 0.0192 | 0.1343 | 1 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0133 | 0.0753 | 0.4938 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0188 | 0.1301 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.0192 | 0.1343 | 1 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0188 | 0.1301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0753 | 0.5121 |
Echinococcus multilocularis | biotin protein ligase | 0.0188 | 0.1301 | 0.9643 |
Echinococcus multilocularis | biotin protein ligase | 0.0188 | 0.1301 | 0.9643 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.0188 | 0.1301 | 0.9643 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0133 | 0.0753 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0188 | 0.1301 | 1 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0188 | 0.1301 | 1 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0188 | 0.1301 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0188 | 0.1301 | 1 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0188 | 0.1301 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.0177 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0655 | 0.601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0753 | 0.5121 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0188 | 0.1301 | 0.969 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0188 | 0.1301 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0188 | 0.1301 | 1 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0188 | 0.1301 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Giardia lamblia | Hypothetical protein | 0.0188 | 0.1301 | 0.5 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0192 | 0.1343 | 1 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0192 | 0.1343 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0192 | 0.1343 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | uM | Inhibitory activity against Selectin E using cell-cell assay; Not tested | ChEMBL. | 11405647 |
IC50 (functional) | 0 uM | Inhibitory activity against Selectin E using cell-cell assay; Not tested | ChEMBL. | 11405647 |
IC50 (binding) | = 21 uM | Inhibitory activity against P-selectin using cell-selectin protein assay | ChEMBL. | 11405647 |
IC50 (binding) | = 21 uM | Inhibitory activity against P-selectin using cell-selectin protein assay | ChEMBL. | 11405647 |
IC50 (binding) | = 100 uM | Inhibitory activity against P-selectin using ELISA-based assay | ChEMBL. | 11405647 |
IC50 (binding) | = 100 uM | Inhibitory activity against P-selectin using ELISA-based assay | ChEMBL. | 11405647 |
IC50 (functional) | = 123 uM | Inhibitory activity against P-selectin using cell-cell assay | ChEMBL. | 11405647 |
IC50 (functional) | = 123 uM | Inhibitory activity against P-selectin using cell-cell assay | ChEMBL. | 11405647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.