Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.1907 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.297 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.297 | 1 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.1907 | 1 |
Onchocerca volvulus | 0.0023 | 0.297 | 1 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.297 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.297 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.297 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1907 | 0.6421 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1907 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.1907 | 0.6421 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.297 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.