TDR Targets

Basic information

Technical information

TDR Targets ID: 1065786
Name: 5-chloro-N-[2-ethyl-1-(2-phenylpyrazol-3-yl)b utyl]thiophene-2-sulfonamide
MW: 423.98 | Formula: C19H22ClN3O2S2
H donors: 1 H acceptors: 3 LogP: 5.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCC(C(c1ccnn1c1ccccc1)NS(=O)(=O)c1ccc(s1)Cl)CC
InChi: 1S/C19H22ClN3O2S2/c1-3-14(4-2)19(22-27(24,25)18-11-10-17(20)26-18)16-12-13-21-23(16)15-8-6-5-7-9-15/h5-14,19,22H,3-4H2,1-2H3
InChiKey: WZPMLPHKGKPPSV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-chloro-N-[2-ethyl-1-(2-phenyl-3-pyrazolyl)butyl]-2-thiophenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.099	0.099
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.099	0.099
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.099	0.099
Toxoplasma gondii	kringle domain-containing protein	0.003	0.2782	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.099	0.099
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.099	0.099
Brugia malayi	TAR-binding protein	0.0067	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Leishmania major	hypothetical protein, conserved	0.003	0.2782	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.2782	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0034	0.3516	0.3516
Loa Loa (eye worm)	TAR-binding protein	0.0067	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.099	0.099
Echinococcus granulosus	tissue type plasminogen activator	0.003	0.2782	0.2782
Schistosoma mansoni	tar DNA-binding protein	0.0067	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.099	0.099
Schistosoma mansoni	hypothetical protein	0.0034	0.3516	0.3516
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.6023	0.6023
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.099	0.099
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.099	0.099
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.099	0.099
Brugia malayi	Protein kinase domain containing protein	0.003	0.2782	0.2782
Schistosoma mansoni	tar DNA-binding protein	0.0067	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.099	0.099
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.6023	0.6023
Loa Loa (eye worm)	hypothetical protein	0.003	0.2782	0.2782
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.099	0.099
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.099	0.099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.099	0.099
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.3516	0.3516
Schistosoma mansoni	tar DNA-binding protein	0.0067	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.099	0.099
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.099	0.099
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.6546	0.6546
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.099	0.099
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.003	0.2782	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0067	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.099	0.099
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.099	0.099
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.6023	0.6023
Echinococcus multilocularis	tar DNA binding protein	0.0067	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.6023	0.6023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.6023	0.6023
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.099	0.099
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.6546	0.6546
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.099	0.099
Loa Loa (eye worm)	RNA binding protein	0.0067	1	1
Echinococcus multilocularis	tissue type plasminogen activator	0.003	0.2782	0.2782
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.099	0.099
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.099	0.099
Brugia malayi	ecdysteroid receptor	0.0021	0.099	0.099
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.099	0.099
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.099	0.099
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.6023	0.6023
Onchocerca volvulus		0.003	0.2782	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.099	0.099
Brugia malayi	nuclear hormone receptor	0.0021	0.099	0.099
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.6023	0.6023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.099	0.099
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.099	0.099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.6023	0.6023
Brugia malayi	nuclear receptor NHR-88	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.099	0.099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.099	0.099
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.099	0.099
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.099	0.099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.099	0.099
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.005	0.6546	0.6546
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.099	0.099
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.099	0.099
Brugia malayi	Kringle domain containing protein	0.003	0.2782	0.2782
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.099	0.099
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.099	0.099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.6023	0.6023
Echinococcus granulosus	tar DNA binding protein	0.0067	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.099	0.099
Schistosoma mansoni	tar DNA-binding protein	0.0067	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.099	0.099
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.099	0.099
Plasmodium falciparum	cysteine repeat modular protein 1	0.003	0.2782	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.003	0.2782	0.2782
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.099	0.099
Schistosoma mansoni	coup transcription factor	0.0021	0.099	0.099
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.099	0.099
Brugia malayi	steroid hormone receptor	0.0021	0.099	0.099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.099	0.099
Schistosoma mansoni	hypothetical protein	0.003	0.2782	0.2782
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.6546	0.6546

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL572426

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1065786