Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 10 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.0814 | 0.0814 |
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0814 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1589 | 0.1589 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0068 | 0.1589 | 0.1478 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | 0.0056 | 0.0678 | 0.0555 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0814 | 0.0692 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.3753 | 0.3671 |
Loa Loa (eye worm) | disintegrin family protein | 0.0074 | 0.2064 | 0.2064 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0102 | 0.4146 | 0.4068 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3677 | 0.3593 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0814 | 0.0692 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.3753 | 0.3671 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3677 | 0.3593 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3753 | 0.3671 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 1 | 1 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0102 | 0.4146 | 0.4068 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0102 | 0.4146 | 0.4068 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0248 | 0.0119 |
Brugia malayi | Matrixin family protein | 0.0051 | 0.0316 | 0.0187 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3753 | 0.3671 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.0814 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3677 | 0.3593 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0077 | 0.2238 | 0.2135 |
Loa Loa (eye worm) | matrixin family protein | 0.0051 | 0.0316 | 0.0316 |
Brugia malayi | Disintegrin family protein | 0.0102 | 0.4146 | 0.4068 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.0814 | 0.0692 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0077 | 0.2238 | 0.2135 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0814 | 0.0692 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.3753 | 0.3671 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0814 | 0.0692 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0068 | 0.1589 | 0.1478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.