Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4964 | 0.4964 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0835 | 0.597 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0078 | 0.0672 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0672 | 0.4801 |
Trypanosoma cruzi | squalene synthase, putative | 0.0251 | 0.2821 | 0.2304 |
Trypanosoma cruzi | squalene synthase, putative | 0.0251 | 0.2821 | 0.2304 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0827 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0084 | 0.074 | 0.074 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0078 | 0.0672 | 0.4801 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0084 | 0.074 | 0.5287 |
Brugia malayi | Peptidase family M28 containing protein | 0.0136 | 0.1399 | 0.1399 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 0.1399 | 1 |
Leishmania major | squalene synthase, putative | 0.0251 | 0.2821 | 0.2304 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 0.1399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0672 | 0.0672 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0827 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0835 | 0.597 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1399 | 0.1399 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0078 | 0.0671 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0078 | 0.0671 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0078 | 0.0672 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0084 | 0.074 | 0.074 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0827 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 0.1399 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0078 | 0.0672 | 0.4801 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0084 | 0.074 | 0.5287 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 0.1399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0827 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 90 % | Inhibition of human glutaminyl cyclase overexpressed in HEK293 cells coexpressing amyloid precursor protein assessed as reduction in pGlu-Abeta-3(pE)-40,42 peptide formation at 1 uM relative to 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea | ChEMBL. | 19863057 |
Ki (binding) | = 18 nM | Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay | ChEMBL. | 19863057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.