Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 1.94 | Calculated partition coefficient (clogP) | ChEMBL. | 1597859 |
IC50 (binding) | = 0.11 uM | Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations. | ChEMBL. | 1597859 |
IC50 (binding) | = 0.11 uM | Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations. | ChEMBL. | 1597859 |
Inhibition (functional) | = 68 % | Tested in vivo for the inhibition of cholesterol biosynthesis in chow-fed rats at 1.0 mg/kg. | ChEMBL. | 1597859 |
Inhibition (functional) | = 68 % | Tested in vivo for the inhibition of cholesterol biosynthesis in chow-fed rats at 1.0 mg/kg. | ChEMBL. | 1597859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.